3-(Ethoxycarbonyl)Pyridine-5-Boronic Acid Pinacol Ester

3-(Ethoxycarbonyl)Pyridine-5-Boronic Acid Pinacol Ester - Names and Identifiers

Name	ethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate
Synonyms	5-(Ethoxycarbonyl)pyridine-3-bor ETHYL NICOTINATE-5-PINACOLBORONATE Nictinic acid ethyl ester-5-boronic acid pinacol ester NICOTINIC ACID ETHYL ESTER-5-BORONIC ACID PINACOL ESTER 3-(Ethoxycarbonyl)Pyridine-5-Boronic Acid Pinacol Ester 5-(Ethoxycarbonyl)pyridine-3-boronic acid pinacol ester 3-(ETHOXYCARBONYL)PYRIDINE-5-BORONIC ACID PINACOL ESTER ethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate ETHYL 5-(TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE-3-CARBOXYLATE 5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-NICOTINIC ACID ETHYL ESTER 5-(4,4,5,5-Teteramethyl-[1,3,2]dioxaboroane-2-yl)-nicotinic acid ethyl ester
CAS	916326-10-8
InChI	InChI=1S/C14H20BNO4/c1-6-18-12(17)10-7-11(9-16-8-10)15-19-13(2,3)14(4,5)20-15/h7-9H,6H2,1-5H3

3-(Ethoxycarbonyl)Pyridine-5-Boronic Acid Pinacol Ester - Physico-chemical Properties

Molecular Formula	C14H20BNO4
Molar Mass	277.12
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

3-(Ethoxycarbonyl)Pyridine-5-Boronic Acid Pinacol Ester - Introduction

Ethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate is an organic compound with the formula C15H21BNO5.

Nature:
-Appearance: Colorless to light yellow solid
-Melting point: about 70-72 ℃
-Solubility: Soluble in most organic solvents such as ether, dichloromethane and methanol

Use:
-as an important reagent and intermediate in organic synthesis
-can be used to synthesize compounds containing pyridine skeleton
-In the field of drug synthesis and pesticide synthesis and other applications

Method:
the preparation of ethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate can be completed by ester exchange reaction, the specific steps are as follows:
1.5-Chloro -2,3-dimethylpyridine reacts with ethyl acetate under alkaline conditions to generate ethyl N-(5-chloro-2, 3-dimethylpyridin-2-yl) acetate.
2. the product obtained in the previous step is subjected to palladium-catalyzed transesterification reaction with 4,4,5,5-tetramethyl-1,3, 2-dioxole-2-ene-2-boronic acid to produce the final product ethyl 5-(4,4, 5,5-tetramethyyl-1, 3,2-dioxaborolan-2-yl)nicotinate.

Safety Information:
ethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate has limited safety information, so general chemical laboratory safety procedures should be followed during operation or use. This includes wearing appropriate personal protective equipment (e. g., lab gloves, goggles, lab coats, etc.) and avoiding inhalation, ingestion, or contact with the compound. When using this compound, ensure that the operating environment is well ventilated and that waste is properly disposed. In case of inhalation, ingestion or skin contact, seek medical attention immediately.

Last Update：2024-04-09 20:49:11